Considering the growing relevance of antimicrobial resistance (AMR), as well as the increasing misuse of broad-spectrum antibiotics, our current project aims to develop a rapid test capable of simultaneously identifying multiple antimicrobial resistance genes. 

Our goal is to support medical professionals in quickly selecting an appropriate antibiotic, for example, in cases such as urinary tract infections or infected wounds. 

Our rapid test utilizes the so-called “genetic scissors”, a CRISPR-Cas system, combined with inorganic catalysts. These components are integrated into a smart, chip-based setup that can be interpreted either manually or using a digital interface. 

By enabling faster and more efficient selection of effective antibiotics in clinics and outpatient settings, we also work towards the actualization of several UN Sustainable Development Goals (https://sdgs.un.org/goals). 

To achieve this, our team consists of four research teams that take on different parts of the project. One team focuses on identifying specific sequences that indicate antimicrobial resistance, while another works towards optimizing the CRISPR-Cas system. As we plan to use inorganic catalysts, a third team is dedicated to the synthesis and modification of nanoparticles. The fourth team develops the chip system that will work with our detection mechanism. 

Beyond the technical development, our project also addresses broader societal implications. As we aim to create a tool for fast and accessible DNA analysis, we must carefully consider potential dual-use concerns. A rapid test like ours has the potential to transform the world for the better. It could increase the accessibility of diagnostics without special knowledge or equipment and therefore be a step towards the democratization of diagnostics which offers significant benefits, especially for resource-limited settings. On the other hand, accessibility without sufficient expertise increases the probability of misuse. These and other potential risks need to be evaluated carefully. 

To continuously reflect on and improve our project, we actively engage with experts and the wider community. We are in contact with healthcare professionals to gather a better understanding of patient interactions and real-world implementation. We are also meeting other iGEM teams as we are hosting the third BFH European meet-up, a yearly student-led meet-up for iGEM teams to network, give each other feedback and expand our skillsets in workshops. Furthermore, we take on an educational role by attending multiple events to present our project to students, get their feedback and input and spark their interest in science.